Bradley B. Keller , M.D
Division Chief, Pediatric Heart Research
Bradley B. Keller, M.D., Kosair Charities chair and director of the Cardiovascular Innovation Institute’s Kosair Charities Pediatric Heart Research Center, directs pediatric heart research at the CII. Dr. Keller also serves as the vice-chair for research with the department of Pediatrics at the University of Louisville and provides inpatient and outpatient care for children and adults with congenital heart disease as a tenured professor in the department of Pediatrics, Division of Pediatric Cardiology at the University of Louisville.
Graduating from the University of Pennsylvania with a Bachelor of Arts degree in biology and genetics, Dr. Keller then received his Doctorate in Medicine at Pennsylvania State University in Hershey, PA. Dr. Keller went on to complete his pediatric residency at the Johns Hopkins Hospital in Baltimore and a Fellowship in pediatric cardiology at the University of Rochester School of Medicine in Rochester, New York. Dr. Keller served as program principal investigator for the Specialized Center of Research for Pediatric Cardiovascular Diseases at the University of Rochester from 1993 to 1998. He also served as the principal investigator for numerous investigator-initiated research grants, including the administration of research projects and resources.
His past positions include chief of the division of Pediatric Cardiology at the University of Kentucky from 1998 to 2002 and chief of the division of Pediatric Cardiology and co-director of the Heart Center at the Children’s Hospital of Pittsburgh of UPMC from 2002 to 2006. Dr. Keller is an adjunct faculty member in the department of Biomedical Engineering at Carnegie Mellon University and actively collaborates with faculty in the departments of Bioengineering at the University of Pittsburgh and Carnegie Mellon University. He served on the University of Pittsburgh Technology Transfer committee. He served as director for the Summer Student Research Program at the Children’s Hospital of Pittsburgh of UPMC from 2003 to 2008. As the medical director for the Touching Hearts in Tibet, Dr. Keller coordinates the identification and treatment of children and adults with heart disease in the high altitude Tibet Autonomous Region. To date the program has screened more than 22,000 children and successfully treated more than 250 children with heart catheterization and intervention or cardiac surgery.
The major basic science focus of Dr. Keller’s research program has been investigating the regulation of cardiovascular morphogenesis and functional maturation via biomechanical load and epigenetic factors (hypoxia, caffeine). A second basic science focus of Dr. Keller’s research program has been the application of tissue engineering approaches to develop cardiomyocyte-derived tissues for cardiac repair and regeneration. The translational focus of Dr. Keller’s research is on the development of innovative and novel biomedical technologies to meet the unique needs of pediatric patients through multidisciplinary teams of clinicians, scientists, and engineers. Examples of these technologies include projects to develop implantable ventricular assist devices for infants and children, the development of image-guided navigation solutions for interventional procedures and vascular access, and the development of pediatric wireless technology applications for heart rhythm detection and analysis.